Drug Abuse
How to Tell if Someone is High: Signs and Symptoms
Medically Reviewed By
Written By
Last medically reviewed May 19, 2025
Drug Abuse
Medically Reviewed By
Written By
Last medically reviewed May 19, 2025
Drug and alcohol use may be easy to hide, but the signs of being under their influence are significantly harder to conceal. This is due to changes in the brain that lead to physical, psychological, and behavioral alterations shortly after use. These changes can last from several hours to an entire day and vary in severity. However, severe symptoms typically indicate a high resulting from consuming a toxic amount, also referred to as an overdose.[1]
In this guide, you’ll discover what causes a drug high and the psychological, behavioral, and physical signs someone is using them.
Cognition is a blanket term incorporating processes such as memory, thinking, attention, and language.[2] It is controlled by the prefrontal cortex, an important part of the brain located behind the forehead.[3] When working normally, it receives signals from the brainstem, activating these processes. Drug misuse, however, disrupts these signals, causing cognitive delay. This results in the cognitive signs of being high.[4]
Many of these signs are temporary and will wear off when the drug is completely detoxed from the system. However, it’s important to note that not all drugs are created equally. Substances like cannabis can have long-term effects that last for months and even years after the last use.[5]
A person influenced by drugs can show various physical signs of being high. These signs persist for hours after drug use, gradually diminishing. Many of them are due to disruptions in how the brain transmits and receives signals. This leads to widespread impairments that are hard to conceal.
If your loved one is under the influence of an addictive substance, they may display the following physical signs:[6]
It’s important to note that many of the above-listed signs overlap with symptoms of depression or other mental health disorders. Therefore, displaying these signs alone is not indicative of drug use.
Drugs, such as methamphetamines, hallucinogens, and stimulants, cause sudden behavioral changes. This is because they send abnormal messages to neurons in the body, causing them to alter important brain areas that control motivation and impulses.[4] They also activate the extended amygdala, which controls stress and anxiety. Unfortunately, this part of the brain becomes very sensitive with increased drug use. This results in anxiousness and nervousness, amongst other behavior signs.
They include:[7]
Some people may want to argue or fight when under the influence, though this is more likely with stimulant drug use. They may also take more risks than usual, leading to increased accidents and family disagreements.
Many substances, both legal and illegal, change how a person thinks and judges, potentially leading to addiction.
According to the National Institute on Drug Abuse, these substances include:[8]
There is no standard timeframe for how long a drug high lasts, as the duration of effects varies based on several factors. These include the drug class, the amount consumed, the form in which it is taken, and the method of use. Generally, a drug is eliminated from the body in four to five times its elimination half-life. Therefore, it is safe to say that most symptoms of a drug high will be completely gone within that time. [9]
Commonly abused substances and their elimination half-lives include:
Using drugs repeatedly can result in tolerance, dependence, and addiction. To quit drugs and alcohol, it’s essential to identify the reasons behind your substance use and recognize the triggers that compel you to use, even when it adversely affects you and those around you. This process requires acknowledgment and honesty, along with support from qualified professionals who employ scientifically supported methods and FDA-approved medications for assistance.
If you’re in Georgia, contact Southeast Detox, GA, to learn about our treatment options for substance abuse and addiction and how we’ve helped thousands of people overcome addiction and remain sober.
A person with a drug or alcohol abuse problem may be facing significant life challenges. It’s best not to confront them about their substance use but rather to talk to them lovingly and express your concerns. Let them know that you care about them and want what’s best for them. Explain your worries without being judgmental. Listen to their responses and offer your support and resources.
Withdrawal symptoms can closely mimic those of being under the influence. This occurs as the brain struggles to regulate without the presence of the addictive substance. If someone you know is experiencing drug withdrawal, contact Southeast Detox GA to learn about our medication-assisted detoxification and drug addiction treatment programs.
Some symptoms can overlap, though overdose symptoms are much more pronounced and, in many cases, life-threatening. They are also more likely to occur in individuals with substance use disorder.
[1] National Harm Reduction Coalition. (n.d.) Opioid Overdose Basics. Retrieved from https://harmreduction.org/issues/overdose-prevention/overview/overdose-basics/what-is-an-overdose/2025 on 2025 Mar 12.
[2] American Psychological Association. (n.d) Cognition and the Brain. Retrieved from https://www.apa.org/topics/cognition-brain on 2025 Mar 12.
[3] National Library of Medicine. (2021 Jun 11) The Role of the Medial Prefrontal Cortex in Cognition, Ageing and Dementia. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC8249104/ on 2025 Mar 12.
[4] National Institute on Drug Abuse. (n.d.) Drugs, Brains, and Behavior: The Science of Addiction. Retrieved from https://nida.nih.gov/publications/drugs-brains-behavior-science-addiction/drugs-brain on 2025 Mar 12.
[5] Harvard Health Publishing. (2022 Jun 14) Cognitive Effects in Midlife of Long-Term Cannabis Use. Retrieved from https://www.health.harvard.edu/blog/cognitive-effects-of-long-term-cannabis-use-in-midlife-202206142760 on 2025 Mar 12.
[6] Indian Health Service. (n.d.) Warning Signs of Substance and Alcohol Use Disorder. Retrieved from https://www.ihs.gov/asab/familyfriends/warningsignsdrug on 2025 Mar 12.
[7] Mental Health Foundation. (2021 Sep 14) Drugs and Mental Health. Retrieved from https://www.mentalhealth.org.uk/explore-mental-health/a-z-topics/drugs-and-mental-health on 2025 Mar 12.
[8] National Institute on Drug Abuse. (2023 Sep 19) Commonly Used Drug Charts. Retrieved from https://nida.nih.gov/research-topics/commonly-used-drugs-charts on 2025 Mar 12.
[9] StatPearls. (2023 Jun 20) Half-Life. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK554498/ on 2025 Mar 12.
[10] National Library of Medicine. (2005) Pharmacokinetics of Cannabinoids. Retrieved from https://pubmed.ncbi.nlm.nih.gov/16237477/ on 2025 Mar 12.
[11] VeryWell Med. (2024 Aug 4) How Long Does Alcohol Stay in Your System? Retrieved from https://pubmed.ncbi.nlm.nih.gov/16237477/ on 2025 Mar 12.
[12] National Library of Medicine. (2009 Jul) A Review of the Clinical Pharmacology of Methamphetamine. Retrieved from https://pubmed.ncbi.nlm.nih.gov/19426289/ on 2025 Mar 12.
[13] StatPearls. (2023 Sep 4) Phencyclidine Toxicity. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK507865/ on 2025 Mar 12.
[14] National Library of Medicine. (2000 Sep) Pharmacology of MDMA in Humans. Retrieved from https://pubmed.ncbi.nlm.nih.gov/11085324/ on 2025 Mar 12.
[15] National Library of Medicine. (2000 Oct) Elimination of Cocaine and Metabolites in Plasma, Saliva, and Urine Following Repeated Oral Administration to Human Volunteers. Retrieved from https://pubmed.ncbi.nlm.nih.gov/11043648/ on 2025 Mar 12.
[16] U.S. Food and Drug Administration. (2007 Mar) Adderall. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/011522s040lbl.pdf on 2025 Mar 12.
[17] Australian Government. (n.d.) Product Information: OxyContin Tablets. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/011522s040lbl.pdf on 2025 Mar 12.
[18] National Library of Medicine. (2013) Benzodiazepine Pharmacology and Central Nervous System Mediated Effects. Retrieved from https://pmc.ncbi.nlm.nih.gov/articles/PMC3684331/ on 2025 Mar 12.